Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
PAE1328Conserved hypothetical protein. (279 aa)    
Predicted Functional Partners:
PAE1327
uracil-DNA glycosylase (Pa-UDGb); DNA glycosylase with broad substrate specificity. Can remove uracil from double-stranded DNA containing either a U/G or U/A base pair. Can also process hydroxymethyluracil (mispaired with guanine or adenine), hypoxanthine and fluorouracil. Exhibits a clear preference for double-stranded DNA substrates, but can also process uracil in single-stranded DNA, with lower efficiency. Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.
       0.779
PAE1326
Hypothetical protein.
       0.773
PAE1329
Conserved hypothetical protein; Belongs to the thioesterase PaaI family.
       0.754
PAE1330
2-isopropylmalate synthase (leuA); Amino acid biosynthesis; Pyruvate family; Belongs to the alpha-IPM synthase/homocitrate synthase family.
       0.595
PAE3513
Resolvase, conjectural; DNA metabolism; DNA replication, recombination, and repair.
  
    0.529
PAE0573
Conserved hypothetical protein.
 
    0.465
PAE0600
Conserved hypothetical protein.
 
 
 0.417
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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