Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
PAE1597Aminopeptidase; Unclassified. (822 aa)    
Predicted Functional Partners:
PAE3371
Gamma-glutamyltransferase; Biosynthesis of cofactors, prosthetic groups, and carriers; Glutathione.
  
 
 0.912
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 0.874
PAE1964
Aspartate aminotransferase (aspC), conjectural; Amino acid biosynthesis; Aspartate family.
 
  
 0.852
PAE2251
Aspartate aminotransferase (aspC), conjectural; Amino acid biosynthesis; Aspartate family.
    
 0.830
upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
  
    0.827
PAE0049
Serine protease inhibitor (serpin); Protein fate; Degradation of proteins, peptides, and glycopeptides; Belongs to the serpin family.
 
 
 0.791
fusA
Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...]
  
 
 0.767
PAE2480
Aldehyde dehydrogenase; Unclassified.
  
 0.642
PAE1651
Isocitrate dehydrogenase; Energy metabolism; TCA cycle.
    
 0.638
PAE3023
Carbon nitrogen hydrolase, conjectural; Unclassified.
 
 0.631
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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