Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE1651Isocitrate dehydrogenase; Energy metabolism; TCA cycle. (439 aa)    
Predicted Functional Partners:
PAE1499
Aconitate hydratase; Energy metabolism; TCA cycle.
  
 0.997
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily.
  
 0.988
sucC
succinyl-CoA synthetase beta subunit (sucC); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.962
PAE1996
Amino acid biosynthesis; Glutamate family; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.937
PAE3438
Amino acid biosynthesis; Glutamate family; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.937
PAE1689
Citrate synthase; Energy metabolism; TCA cycle.
 
 0.929
PAE3584
Citrate synthase part 1, authentic frameshift; Energy metabolism; TCA cycle.
 
 0.929
PAE1995
3-isopropylmalate dehydrogenase (leuB); Amino acid biosynthesis; Pyruvate family.
  
 0.928
PAE3585
Citrate synthase part 2, authentic frameshift; Energy metabolism; TCA cycle.
  
 0.919
PAE0939
2-oxoacid ferredoxin oxidoreductase alpha subunit; Energy metabolism; Electron transport.
  
 
 0.918
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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