Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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PAE1678Conserved hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity). (147 aa)    
Predicted Functional Partners:
rtcB
Conserved hypothetical protein; GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair (By similarity). Joins RNA with 2',3'- cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends (By similarity); Belongs to the RtcB family.
 
 0.993
PAE1677
Conserved hypothetical protein.
       0.792
PAE1676
Hypothetical protein.
       0.791
rtcA
RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
 
 
 
 0.756
prf1
Peptide chain release factor aRF subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
  
    0.722
PAE1679
D-arabino 3-hexulose 6-phosphate formaldehyde lyase, conjectural; Energy metabolism; Sugars.
 
     0.639
adkA
Adenylate kinase; Purines, pyrimidines, nucleosides, and nucleotides; Nucleotide and nucleoside interconversions; Belongs to the archaeal adenylate kinase family.
       0.593
PAE0743
RNA binding protein (fmu, PCNA P120 homolog), probable; Protein fate; Protein modification and repair.
 
   
 0.585
PAE1674
Hypothetical protein.
       0.480
PAE0296
Helix-turn-helix protein, conjectural; Transcription; Transcription factors.
       0.470
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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