Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE1679D-arabino 3-hexulose 6-phosphate formaldehyde lyase, conjectural; Energy metabolism; Sugars. (216 aa)    
Predicted Functional Partners:
PAE1489
Conserved protein with sugar isomerase (SIS) domain; Unclassified.
 
 0.999
PAE1027
Ribose 5-phosphate isomerase; Energy metabolism; Pentose phosphate pathway.
 
  
 0.958
adkA
Adenylate kinase; Purines, pyrimidines, nucleosides, and nucleotides; Nucleotide and nucleoside interconversions; Belongs to the archaeal adenylate kinase family.
       0.765
PAE3324
Conserved hypothetical protein.
       0.653
PAE1678
Conserved hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).
 
     0.639
PAE0688
Multiple sugar transport permease protein; Transport and binding proteins; Carbohydrates, organic alcohols, and acids.
   
    0.581
PAE1323
Multiple sugar transport permease; Transport and binding proteins; Carbohydrates, organic alcohols, and acids.
   
    0.581
PAE3456
Maltose ABC transporter, permease protein; Transport and binding proteins; Carbohydrates, organic alcohols, and acids.
   
    0.581
PAE1677
Conserved hypothetical protein.
       0.575
PAE1676
Hypothetical protein.
       0.573
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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