Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE1774Conserved hypothetical protein. (223 aa)    
Predicted Functional Partners:
PAE3655
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Amino acid biosynthesis; Aspartate family.
 
  
 0.941
PAE2420
Cystathionine gamma-synthase; Amino acid biosynthesis; Aspartate family.
  
 
 0.867
PAE1773
H+-transporting ATP synthase subunit I (atpI), conjectural; Energy metabolism; ATP-proton motive force interconversion; Belongs to the V-ATPase 116 kDa subunit family.
 
   
 0.829
PAE2868
Homoserine dehydrogenase; Amino acid biosynthesis; Aspartate family.
  
  
 0.744
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
  
 0.701
PAE1775
Conserved hypothetical protein.
  
  
 0.698
PAE2877
Aspartate kinase; Amino acid biosynthesis; Aspartate family.
  
  
 0.681
PAE1519
Conserved hypothetical protein.
  
  
 0.594
folD
Methylenetetrahydrofolate dehydrogenase (folD); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.593
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
  
 0.583
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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