Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE1872Isocitrate lyase; Central intermediary metabolism; Other. (349 aa)    
Predicted Functional Partners:
PAE1287
Malate synthase (glcB); Central intermediary metabolism; Other.
 
 0.982
PAE1499
Aconitate hydratase; Energy metabolism; TCA cycle.
  
 0.946
sucD
succinyl-CoA synthetase alpha subunit (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 0.930
sucC
succinyl-CoA synthetase beta subunit (sucC); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.922
PAE1038
D-3-phosphoglycerate dehydrogenase (serA); Amino acid biosynthesis; Serine family; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 
 0.920
prpB
Carboxyphosphonoenolpyruvate phosphonomutase (prpB); Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
  
  
 
0.911
PAE2315
Unclassified.
    
 0.910
PAE1284
Glycolate oxidase subunit glcE; Central intermediary metabolism; Other.
     
 0.904
PAE1286
Glycolate oxidase subunit glcD; Central intermediary metabolism; Other.
     
 0.904
PAE2035
D-lactate dehydrogenase; Energy metabolism; Fermentation.
     
 0.904
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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