Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
PAE1983Aerolysin, part 2, authentic frameshift; Protein fate; Degradation of proteins, peptides, and glycopeptides. (214 aa)    
Predicted Functional Partners:
PAE1982
Aerolysin, part 1, authentic frameshift; Protein fate; Degradation of proteins, peptides, and glycopeptides.
     0.958
leuC
3-isopropylmalate dehydratase large subunit (leuC); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
       0.687
nep1
Conserved hypothetical protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
     
 0.671
rpoL
DNA-directed RNA polymerase subunit L (rpoL); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
       0.639
PAE1981
Hypothetical protein.
       0.639
PAE1976
Conserved hypothetical protein.
       0.440
rpl40e
Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eL40 family.
   
 
  0.430
PAE1861
Hypothetical protein with 4 ankyrin repeats; Unclassified.
  
 
 0.423
PAE1189
Acylamino-acid-releasing enzyme, conjectural; Protein fate; Protein modification and repair.
  
 
 0.416
rpl10e
Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the universal ribosomal protein uL16 family.
  
 
 0.408
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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