STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Coexpression
Experiments
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[Homology]
Score
leuA2-isopropylmalate synthase (leuA) with possible unusual start codon; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). (364 aa)    
Predicted Functional Partners:
leuD
3-isopropylmalate dehydratase small subunit (leuD); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
  
 
 0.987
leuC
3-isopropylmalate dehydratase large subunit (leuC); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
 
 0.982
ilvE
Branched-chain amino acid aminotransferase (ilvE); Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
 
 0.980
ilvD
Dihydroxy-acid dehydratase (ilvD); Amino acid biosynthesis; Pyruvate family; Belongs to the IlvD/Edd family.
 
 
 0.958
PAE3300
Acetolactate synthase large subunit (ilvB); Amino acid biosynthesis; Pyruvate family.
 
 
 0.953
PAE1995
3-isopropylmalate dehydrogenase (leuB); Amino acid biosynthesis; Pyruvate family.
 
 
 0.943
PAE1220
acetyl-CoA C-acetyltransferase; Fatty acid and phospholipid metabolism; Degradation.
  
 
 0.935
PAE1377
acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.
  
 
 0.935
PAE2183
acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.
  
 
 0.935
PAE2471
acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.
  
 
 0.935
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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