leuA protein (Pyrobaculum aerophilum) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

leuA

2-isopropylmalate synthase (leuA) with possible unusual start codon; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). (364 aa)

Predicted Functional Partners:

leuD

0.989

ilvE

0.981

leuC

0.979

ilvD

0.978

PAE1220

0.935

PAE1377

0.935

PAE2486

0.935

PAE2488

0.935

PAE3300

0.935

PAE3656

0.935

Your Current Organism:

Pyrobaculum aerophilum

NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PAE1220	PAE1377	PAE1220	PAE1377	acetyl-CoA C-acetyltransferase; Fatty acid and phospholipid metabolism; Degradation.	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	0.640
PAE1220	PAE2486	PAE1220	PAE2486	acetyl-CoA C-acetyltransferase; Fatty acid and phospholipid metabolism; Degradation.	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	0.600
PAE1220	PAE2488	PAE1220	PAE2488	acetyl-CoA C-acetyltransferase; Fatty acid and phospholipid metabolism; Degradation.	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	0.602
PAE1220	PAE3656	PAE1220	PAE3656	acetyl-CoA C-acetyltransferase; Fatty acid and phospholipid metabolism; Degradation.	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	0.639
PAE1220	leuA	PAE1220	PAE1993	acetyl-CoA C-acetyltransferase; Fatty acid and phospholipid metabolism; Degradation.	2-isopropylmalate synthase (leuA) with possible unusual start codon; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate).	0.935
PAE1377	PAE1220	PAE1377	PAE1220	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	acetyl-CoA C-acetyltransferase; Fatty acid and phospholipid metabolism; Degradation.	0.640
PAE1377	PAE2486	PAE1377	PAE2486	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	0.687
PAE1377	PAE2488	PAE1377	PAE2488	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	0.645
PAE1377	PAE3656	PAE1377	PAE3656	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	0.648
PAE1377	leuA	PAE1377	PAE1993	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	2-isopropylmalate synthase (leuA) with possible unusual start codon; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate).	0.935
PAE2486	PAE1220	PAE2486	PAE1220	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	acetyl-CoA C-acetyltransferase; Fatty acid and phospholipid metabolism; Degradation.	0.600
PAE2486	PAE1377	PAE2486	PAE1377	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	0.687
PAE2486	PAE2488	PAE2486	PAE2488	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	0.948
PAE2486	PAE3656	PAE2486	PAE3656	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	0.600
PAE2486	leuA	PAE2486	PAE1993	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	2-isopropylmalate synthase (leuA) with possible unusual start codon; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate).	0.935
PAE2488	PAE1220	PAE2488	PAE1220	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	acetyl-CoA C-acetyltransferase; Fatty acid and phospholipid metabolism; Degradation.	0.602
PAE2488	PAE1377	PAE2488	PAE1377	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	0.645
PAE2488	PAE2486	PAE2488	PAE2486	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	0.948
PAE2488	PAE3656	PAE2488	PAE3656	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	0.602
PAE2488	leuA	PAE2488	PAE1993	acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.	2-isopropylmalate synthase (leuA) with possible unusual start codon; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate).	0.935

page 1 of 3

Server load: low (20%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2025

Credits

Access

Info

About