STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ogtmethylated-DNA--[protein]-cysteine S-methyltransferase (ogt); Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (148 aa)    
Predicted Functional Partners:
PAE2013
Ferredoxin; Energy metabolism; Fermentation.
       0.678
PAE2011
Conserved hypothetical protein.
       0.659
PAE2017
Phosphoserine phosphatase (serB); Amino acid biosynthesis; Serine family.
  
    0.597
PAE0685
Conserved protein (probable universal stress protein homolog); Cellular processes; Adaptations to atypical conditions.
  
    0.591
PAE1738
Conserved hypothetical protein.
  
    0.591
PAE2384
Universal stress protein family; Cellular processes; Adaptations to atypical conditions.
  
    0.591
PAE0880
DNA-(apurinic or apyrimidinic site) lyase (endonuclease III, PaNth); DNA metabolism; DNA replication, recombination, and repair.
 
   
 0.590
fen
DNA endonuclease rad2 homolog; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...]
   
 
 0.505
truA
tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family.
  
  
 0.489
PAE3199
U/G & T/G mismatch specific glycosylase (Pa-MIG); DNA glycosylase that excises thymine from T/G mismatches and uracil from U/G mismatches. Can also process T/GO and U/GO, but not A/G, T/C and U/C. Has weak AP lyase activity.
 
   
 0.472
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.