Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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Score
PAE2017Phosphoserine phosphatase (serB); Amino acid biosynthesis; Serine family. (216 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 0.964
PAE2316
Threonine dehydratase (ilvA); Amino acid biosynthesis; Pyruvate family.
    
 0.926
PAE2458
Tryptophan synthase alpha subunit; Amino acid biosynthesis; Aromatic amino acid family.
    
 0.915
PAE0257
Tryptophan synthase beta subunit (trpB), authentic frameshift; Amino acid biosynthesis; Aromatic amino acid family.
     
 0.901
trpB
Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
 0.901
hisF
Histidine biosynthesis protein (hisF,cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
  
 0.888
hisB
Imidazoleglycerol-phosphate dehydratase; Amino acid biosynthesis; Histidine family.
  
  
 0.858
hisH
Amidotransferase (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
  
  
 0.845
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Amino acid biosynthesis; Histidine family.
  
  
 0.843
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
  
  
 0.823
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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