Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE2021Conserved hypothetical protein. (152 aa)    
Predicted Functional Partners:
ribH
Riboflavin synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
  
  0.977
ribK
Conserved hypothetical protein; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family.
    
  0.923
PAE2986
GTP cyclohydrolase II; Biosynthesis of cofactors, prosthetic groups, and carriers; Riboflavin, FMN, and FAD.
 
   
 0.867
PAE0309
Chlorohydrolase, conjectural; Unclassified.
 
     0.800
gch3
Conserved hypothetical protein; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family.
 
     0.718
PAE2022
Conserved (helix-turn-helix protein, copG family); Regulatory functions; General.
       0.588
PAE2024
Conserved hypothetical protein.
       0.587
PAE2025
xaa-Pro dipeptidase, putative; Protein fate; Degradation of proteins, peptides, and glycopeptides.
       0.587
PAE0683
Cytidyltransferase; Unclassified.
       0.470
PAE0443
Conserved protein; Cell envelope; Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides.
  
     0.448
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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