Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
PAE2025xaa-Pro dipeptidase, putative; Protein fate; Degradation of proteins, peptides, and glycopeptides. (323 aa)    
Predicted Functional Partners:
PAE2024
Conserved hypothetical protein.
 
 
 
 0.850
PAE2022
Conserved (helix-turn-helix protein, copG family); Regulatory functions; General.
       0.798
PAE1525
Glu-tRNA(Gln) amidotransferase subunit A (gatA); Protein synthesis; tRNA aminoacylation.
 
 
   0.693
map
Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
 
  
 0.617
PAE2021
Conserved hypothetical protein.
       0.587
PAE1917
Pyrroline-5-carboxylate reductase; Amino acid biosynthesis; Glutamate family.
 
 
 0.494
PAE1610
Glucose-6-phosphate isomerase, conjectural; Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency.
 
  
 0.491
PAE1597
Aminopeptidase; Unclassified.
  
 
 0.470
pyrC
Dihydroorotase (pyrC); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
 
 0.455
PAE2075
Nitrilase, conjectural; Unclassified.
  
 
  0.446
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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