Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PAE2095Hypothetical; Conserved within genome. (362 aa)    
Predicted Functional Partners:
PAE1917
Pyrroline-5-carboxylate reductase; Amino acid biosynthesis; Glutamate family.
  
 
 0.844
PAE2096
Bacterial extracellular solute-binding proteins, family 3; Transport and binding proteins; Unknown substrate.
 
  
 0.665
fni
Conserved protein (possible oxidoreductase); Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
  
 
 0.640
PAE3321
Aminotransferase (class 5); Unclassified.
  
 
 0.598
PAE3447
Aminotransferase, class-V; Unclassified.
  
 
 0.598
PAE3300
Acetolactate synthase large subunit (ilvB); Amino acid biosynthesis; Pyruvate family.
    
 0.562
PAE1785
Conserved hypothetical protein.
 
 
 0.553
PAE2936
Conserved hypothetical protein.
   
 0.550
thiI
Thiamine biosynthesis protein (thiI), probable; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
     
 0.541
PAE1131
Flavoprotein reductase, conjectural; Central intermediary metabolism; Sulfur metabolism.
  
 
 0.523
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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