PAE2120 protein (Pyrobaculum aerophilum) - STRING interaction network

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Score

PAE2120

Transcription initiation factor IIB, conjectural; Transcription; Transcription factors. (159 aa)

Predicted Functional Partners:

tfb

0.916

tbp

0.898

rpoH

0.883

rpoP

0.883

rpoD

0.879

tfe

0.878

PAE0665

0.876

rpoN

0.867

rpoK

0.867

PAE1611

0.842

Your Current Organism:

Pyrobaculum aerophilum

NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PAE0665	PAE1611	PAE0665	PAE1611	DNA-directed RNA polymerase subunit B (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Helicase, possible DNA repair rad25; DNA metabolism; DNA replication, recombination, and repair.	0.906
PAE0665	PAE2120	PAE0665	PAE2120	DNA-directed RNA polymerase subunit B (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Transcription initiation factor IIB, conjectural; Transcription; Transcription factors.	0.876
PAE0665	rpoD	PAE0665	PAE0671	DNA-directed RNA polymerase subunit B (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	DNA-directed RNA polymerase subunit D (rpoD); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.	0.999
PAE0665	rpoH	PAE0665	PAE0664	DNA-directed RNA polymerase subunit B (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	DNA-directed RNA polymerase subunit H (rpoH); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.	0.999
PAE0665	rpoK	PAE0665	PAE3271	DNA-directed RNA polymerase subunit B (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family.	0.996
PAE0665	rpoN	PAE0665	PAE0675a	DNA-directed RNA polymerase subunit B (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	DNA-directed RNA polymerase subunit N (rpoN); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family.	0.992
PAE0665	rpoP	PAE0665	PAE2258	DNA-directed RNA polymerase subunit B (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family.	0.987
PAE0665	tbp	PAE0665	PAE2164	DNA-directed RNA polymerase subunit B (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Transcription initiation factor TFIID (TATA-binding); General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.	0.968
PAE0665	tfb	PAE0665	PAE1645	DNA-directed RNA polymerase subunit B (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Transcription initiation factor IIB (TFIIB); Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).	0.876
PAE0665	tfe	PAE0665	PAE0781	DNA-directed RNA polymerase subunit B (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Conserved hypothetical protein; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes [...]	0.961
PAE1611	PAE0665	PAE1611	PAE0665	Helicase, possible DNA repair rad25; DNA metabolism; DNA replication, recombination, and repair.	DNA-directed RNA polymerase subunit B (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.906
PAE1611	PAE2120	PAE1611	PAE2120	Helicase, possible DNA repair rad25; DNA metabolism; DNA replication, recombination, and repair.	Transcription initiation factor IIB, conjectural; Transcription; Transcription factors.	0.842
PAE1611	rpoD	PAE1611	PAE0671	Helicase, possible DNA repair rad25; DNA metabolism; DNA replication, recombination, and repair.	DNA-directed RNA polymerase subunit D (rpoD); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.	0.883
PAE1611	rpoH	PAE1611	PAE0664	Helicase, possible DNA repair rad25; DNA metabolism; DNA replication, recombination, and repair.	DNA-directed RNA polymerase subunit H (rpoH); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.	0.890
PAE1611	rpoK	PAE1611	PAE3271	Helicase, possible DNA repair rad25; DNA metabolism; DNA replication, recombination, and repair.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family.	0.883
PAE1611	rpoN	PAE1611	PAE0675a	Helicase, possible DNA repair rad25; DNA metabolism; DNA replication, recombination, and repair.	DNA-directed RNA polymerase subunit N (rpoN); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family.	0.876
PAE1611	rpoP	PAE1611	PAE2258	Helicase, possible DNA repair rad25; DNA metabolism; DNA replication, recombination, and repair.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family.	0.876
PAE1611	tbp	PAE1611	PAE2164	Helicase, possible DNA repair rad25; DNA metabolism; DNA replication, recombination, and repair.	Transcription initiation factor TFIID (TATA-binding); General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.	0.895
PAE1611	tfb	PAE1611	PAE1645	Helicase, possible DNA repair rad25; DNA metabolism; DNA replication, recombination, and repair.	Transcription initiation factor IIB (TFIIB); Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).	0.842
PAE1611	tfe	PAE1611	PAE0781	Helicase, possible DNA repair rad25; DNA metabolism; DNA replication, recombination, and repair.	Conserved hypothetical protein; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes [...]	0.914