Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Experiments
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[Homology]
Score
PAE2137Hypothetical protein. (126 aa)    
Predicted Functional Partners:
queE
Coenzyme PQQ synthesis protein, conjectural; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
  
  
 0.963
queC
Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
  
  
 0.961
folE
GTP cyclohydrolase I; Biosynthesis of cofactors, prosthetic groups, and carriers; Folic acid.
  
 
 0.894
PAE0317
GTP cyclohydrolase I, conjectural; Biosynthesis of cofactors, prosthetic groups, and carriers; Folic acid.
  
  
 0.887
guaA
GMP synthetase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
     
 0.840
cysS
cysteinyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation.
  
  
 0.697
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
   
 
 0.670
PAE2138
Conserved hypothetical protein.
       0.572
tgtA
Queuine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family.
   
 
 0.543
PAE0583
Porphobilinogen synthase (delta-aminolevulinic acid dehydratase) (hemB); Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin; Belongs to the ALAD family.
     
 0.516
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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