Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE2183acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation. (368 aa)    
Predicted Functional Partners:
PAE2185
3-oxoacyl-[acyl-carrier-protein] synthase; Fatty acid and phospholipid metabolism; Degradation; Belongs to the thiolase-like superfamily. UPF0219 family.
 
 0.999
PAE2184
Conserved protein associated with acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.
 
 
 0.995
PAE1383
3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase; Fatty acid and phospholipid metabolism; Degradation.
  
 0.993
PAE1689
Citrate synthase; Energy metabolism; TCA cycle.
  
 0.958
PAE3584
Citrate synthase part 1, authentic frameshift; Energy metabolism; TCA cycle.
  
 0.958
PAE3585
Citrate synthase part 2, authentic frameshift; Energy metabolism; TCA cycle.
  
 0.958
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.940
PAE2648
Pyruvate dehydrogenase E2 (dihydrolipoamide acetyltransferase); Energy metabolism; Glycolysis/gluconeogenesis.
  
 
 0.939
PAE1330
2-isopropylmalate synthase (leuA); Amino acid biosynthesis; Pyruvate family; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.935
PAE1986
2-isopropylmalate synthase (leuA) with possible unusual start codon; Amino acid biosynthesis; Pyruvate family.
  
 
 0.935
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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