Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
PAE2201Conserved hypothetical protein; Probably involved in the biogenesis of the ribosome. (181 aa)    
Predicted Functional Partners:
rpl37ae
Ribosomal protein L37; Binds to the 23S rRNA.
   
   0.963
rpl30
Protein synthesis; Ribosomal proteins: synthesis and modification.
   
 
 0.959
rps8e
Protein synthesis; Ribosomal proteins: synthesis and modification.
   
 
 0.953
PAE3626
Conserved hypothetical protein.
   
 
 0.937
rpl10
Acidic ribosomal protein P0 (L10E); Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.
   
 
 0.925
PAE3232
Nop family pre-rRNA processing protein; Transcription; RNA processing.
   
   0.923
PAE0759
GTP binding protein, conjectural; Unclassified; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
   
 
 0.918
rrp4
Conserved hypothetical protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
  
    0.915
rpl15e
Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eL15 family.
  
 
 0.914
rpl18a
Protein synthesis; Ribosomal proteins: synthesis and modification.
  
   0.911
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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