Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
psmAProteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (243 aa)    
Predicted Functional Partners:
psmB2
Proteasome, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 
0.943
psmB1
Proteasome beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 
0.941
rpl37ae
Ribosomal protein L37; Binds to the 23S rRNA.
 
  
 0.915
pfdB
Conserved hypothetical protein; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity).
 
 
 0.887
PAE2024
Conserved hypothetical protein.
   
 0.882
rpl15e
Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eL15 family.
 
  
 0.858
rrp42
3' exoribonuclease family protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.
 
  
 0.853
rrp4
Conserved hypothetical protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
 
   
 0.847
rpl4
Ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
 
 
 
 0.795
PAE0696
AAA family ATPase, possible cell division control protein cdc48; Cellular processes; Cell division.
 
 0.792
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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