| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PAE0737 | dnaG | PAE0737 | PAE2112 | Cell division control protein 6 (cdc6), putative; Involved in regulation of DNA replication. | Conserved protein (toprim domain); RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | 0.757 |
| PAE0737 | pcn1 | PAE0737 | PAE3038 | Cell division control protein 6 (cdc6), putative; Involved in regulation of DNA replication. | Proliferating-cell nuclear antigen homolog (PCNA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.670 |
| PAE0737 | priL | PAE0737 | PAE2238 | Cell division control protein 6 (cdc6), putative; Involved in regulation of DNA replication. | Conserved protein (possible primase); Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.980 |
| PAE0737 | rfcL | PAE0737 | PAE0735 | Cell division control protein 6 (cdc6), putative; Involved in regulation of DNA replication. | Replication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.847 |
| PAE0737 | rnhB | PAE0737 | PAE1216 | Cell division control protein 6 (cdc6), putative; Involved in regulation of DNA replication. | Ribonuclease HII (rnhB); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.766 |
| PAE0737 | top6B | PAE0737 | PAE2217 | Cell division control protein 6 (cdc6), putative; Involved in regulation of DNA replication. | DNA topoisomerase VI (type II) subunit b; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. | 0.623 |
| dnaG | PAE0737 | PAE2112 | PAE0737 | Conserved protein (toprim domain); RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | Cell division control protein 6 (cdc6), putative; Involved in regulation of DNA replication. | 0.757 |
| dnaG | pcn1 | PAE2112 | PAE3038 | Conserved protein (toprim domain); RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | Proliferating-cell nuclear antigen homolog (PCNA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.599 |
| dnaG | priL | PAE2112 | PAE2238 | Conserved protein (toprim domain); RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | Conserved protein (possible primase); Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.755 |
| dnaG | rfcL | PAE2112 | PAE0735 | Conserved protein (toprim domain); RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | Replication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.404 |
| dnaG | rnhB | PAE2112 | PAE1216 | Conserved protein (toprim domain); RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | Ribonuclease HII (rnhB); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.650 |
| dnaG | rps8e | PAE2112 | PAE3331 | Conserved protein (toprim domain); RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | Protein synthesis; Ribosomal proteins: synthesis and modification. | 0.665 |
| dnaG | top6A | PAE2112 | PAE2219 | Conserved protein (toprim domain); RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | DNA topoisomerase VI (type II) subunit a; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.625 |
| dnaG | top6B | PAE2112 | PAE2217 | Conserved protein (toprim domain); RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | DNA topoisomerase VI (type II) subunit b; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. | 0.692 |
| dys | rtcB | PAE3487 | PAE0998 | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. | Conserved hypothetical protein; GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair (By similarity). Joins RNA with 2',3'- cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends (By similarity); Belongs to the RtcB family. | 0.652 |
| dys | top6A | PAE3487 | PAE2219 | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. | DNA topoisomerase VI (type II) subunit a; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.817 |
| dys | top6B | PAE3487 | PAE2217 | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. | DNA topoisomerase VI (type II) subunit b; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. | 0.694 |
| pcn1 | PAE0737 | PAE3038 | PAE0737 | Proliferating-cell nuclear antigen homolog (PCNA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | Cell division control protein 6 (cdc6), putative; Involved in regulation of DNA replication. | 0.670 |
| pcn1 | dnaG | PAE3038 | PAE2112 | Proliferating-cell nuclear antigen homolog (PCNA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | Conserved protein (toprim domain); RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | 0.599 |
| pcn1 | priL | PAE3038 | PAE2238 | Proliferating-cell nuclear antigen homolog (PCNA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | Conserved protein (possible primase); Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.924 |
