Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
PAE2240Conserved hypothetical protein. (304 aa)    
Predicted Functional Partners:
PAE2239
Hypothetical protein.
       0.898
guaA
GMP synthetase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
     
 0.657
PAE2041
Hypothetical protein.
 
  
 0.640
PAE2242
Conserved hypothetical protein.
       0.579
priL
Conserved protein (possible primase); Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
       0.536
PAE3407
Conserved hypothetical protein.
   
    0.536
PAE2237
Conserved hypothetical protein; DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double- stranded DNA substrates; Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family.
       0.525
PAE2038
Hypothetical protein.
  
  
 0.438
PAE1688
Malate oxidoreductase (mae); Energy metabolism; Other.
  
    0.421
PAE3193a
Possible heat shock protein, htpX homolog part 1, authentic frameshift; Cellular processes; Adaptations to atypical conditions.
  
    0.421
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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