STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAE2260Agmatinase (speB); Central intermediary metabolism; Polyamine biosynthesis; Belongs to the arginase family. (267 aa)    
Predicted Functional Partners:
speE
Spermidine synthase; Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high- temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to norspermidine and 1,3- diaminopropane to yield norspermine, and to spermidine to yield thermospermine. It can also synthesize thermospermine from putrescine (1,4-diaminobutane) and caldop [...]
 
 
 0.981
PAE2480
Aldehyde dehydrogenase; Unclassified.
  
 0.827
PAE2266
glycyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation.
 
     0.810
PAE2261
Cation efflux system protein, conjectural; Transport and binding proteins; Cations.
     
 0.806
lysJ
Acetylornithine aminotransferase (argD); Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
  
 
 0.784
PAE2646
Pyruvate dehydrogenase E1 beta subunit; Energy metabolism; Glycolysis/gluconeogenesis.
  
 
 0.770
leuS
leucyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
 
 0.767
PAE1499
Aconitate hydratase; Energy metabolism; TCA cycle.
     
 0.766
PAE2268
Protein synthesis; tRNA and rRNA base modification.
       0.758
PAE2743
Fumarate hydratase class II; Energy metabolism; TCA cycle.
     
 0.740
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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