Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE2261Cation efflux system protein, conjectural; Transport and binding proteins; Cations. (296 aa)    
Predicted Functional Partners:
PAE2260
Agmatinase (speB); Central intermediary metabolism; Polyamine biosynthesis; Belongs to the arginase family.
     
 0.806
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily.
  
    0.712
PAE2263
paREP2b; Hypothetical; Conserved within genome.
       0.559
PAE3631
NAD dependent epimerase/dehydratase, putative; Purines, pyrimidines, nucleosides, and nucleotides; Sugar-nucleotide biosynthesis and conversions.
 
  
 0.518
PAE3169
Conserved protein with 7 CBS domains; Unclassified.
 
    0.482
PAE2138
Conserved hypothetical protein.
  
     0.470
PAE2259
Conserved protein (possible cytidylyltransferase); Unclassified.
       0.443
hjc
Holliday Junction Resolvase; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family.
  
     0.438
endA
tRNA intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
 
     0.438
PAE0042
Egghead homolog; Unclassified.
  
     0.437
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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