Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PAE2286ABC transporter ATP-binding protein, putative; Transport and binding proteins; Unknown substrate. (254 aa)    
Predicted Functional Partners:
PAE2288
Conserved hypothetical protein.
 
 
 0.962
PAE2285
Hypothetical protein.
       0.919
PAE3684
Conserved hypothetical protein.
 
 
 0.804
PAE3663
Conserved hypothetical protein.
 
 
 0.802
PAE0039
Conserved hypothetical protein.
 
 
 0.790
PAE2290
Membrane protein, putative; Transport and binding proteins; Unknown substrate.
     
 0.605
PAE2291
Hypothetical protein.
       0.543
rps5
Ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy.
 
   
 0.528
rpl14
Ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.
 
     0.524
hisS
histidyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation; Belongs to the class-II aminoacyl-tRNA synthetase family.
 
   
 0.514
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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