STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAE2295Conserved hypothetical protein. (324 aa)    
Predicted Functional Partners:
PAE3646
Conserved hypothetical protein.
  
  
 
0.923
thiI
Thiamine biosynthesis protein (thiI), probable; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
 
 0.862
PAE2294
Hypothetical protein.
       0.797
PAE2166
Beta-aspartate methyltransferase (pimT), conjectural; Protein fate; Protein modification and repair.
 
  
 0.670
PAE0866
Conserved hypothetical protein.
       0.652
guaA
GMP synthetase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
  
  
 0.632
flpA
Fibrillarin-like pre-rRNA processing protein (flpA); Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.
 
 
 0.631
PAE0922
Conserved hypothetical protein.
   
 
 0.617
PAE1056
thiF/moeB/hesA family protein; Unclassified.
  
 
 0.609
PAE0727
Molybdenum cofactor biosynthesis protein D/E; Biosynthesis of cofactors, prosthetic groups, and carriers; Molybdopterin.
  
 
 0.599
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.