Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PAE2298ATP-dependent helicase; Unclassified. (744 aa)    
Predicted Functional Partners:
PAE2299
Hypothetical; Conserved within genome.
       0.550
PAE1156
Conserved hypothetical protein.
      
 0.485
nfi
DNA endonuclease V, conjectural; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
      
 0.480
PAE2180
DNA-directed DNA polymerase (B1); DNA metabolism; DNA replication, recombination, and repair.
  
 
   0.429
PAE3513
Resolvase, conjectural; DNA metabolism; DNA replication, recombination, and repair.
   
    0.408
PAE3683
Hypothetical protein.
   
    0.404
PAE2301
ABC transporter ATP-binding component, degenerate; Transport and binding proteins; Unknown substrate.
       0.400
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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