STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAE2310Proline dehydrogenase; Amino acid biosynthesis; Serine family. (416 aa)    
Predicted Functional Partners:
PAE2311
Hypothetical protein.
       0.793
PAE2628
Flavoprotein reductase, conjectural; Energy metabolism; Electron transport.
 
 
 0.698
PAE1131
Flavoprotein reductase, conjectural; Central intermediary metabolism; Sulfur metabolism.
  
 
 0.657
PAE1841
Conserved hypothetical protein.
  
 
 0.657
PAE2371
NADH oxidase (nox); Cellular processes; Toxin production and resistance.
  
 
 0.657
PAE2618
Flavoprotein reductase, conjectural; Energy metabolism; Electron transport.
  
 
 0.657
PAE2834
Conserved hypothetical protein.
  
 
 0.657
sucD
succinyl-CoA synthetase alpha subunit (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
  
 0.651
sucC
succinyl-CoA synthetase beta subunit (sucC); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
    0.648
PAE2309
Ferric uptake regulator, putative; Regulatory functions; General.
 
   
 0.617
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.