Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PAE2316Threonine dehydratase (ilvA); Amino acid biosynthesis; Pyruvate family. (403 aa)    
Predicted Functional Partners:
PAE3300
Acetolactate synthase large subunit (ilvB); Amino acid biosynthesis; Pyruvate family.
 
 0.976
PAE2878
Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
 
 
0.971
PAE1995
3-isopropylmalate dehydrogenase (leuB); Amino acid biosynthesis; Pyruvate family.
  
 0.963
ilvE
Branched-chain amino acid aminotransferase (ilvE); Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.951
PAE2458
Tryptophan synthase alpha subunit; Amino acid biosynthesis; Aromatic amino acid family.
  
 
 0.936
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.934
PAE2017
Phosphoserine phosphatase (serB); Amino acid biosynthesis; Serine family.
    
 0.926
PAE0257
Tryptophan synthase beta subunit (trpB), authentic frameshift; Amino acid biosynthesis; Aromatic amino acid family.
    
 0.906
trpB
Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
    
 0.906
ilvD
Dihydroxy-acid dehydratase (ilvD); Amino acid biosynthesis; Pyruvate family; Belongs to the IlvD/Edd family.
  
 
 0.904
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.