Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE2332Alcohol dehydrogenase (Zinc); Energy metabolism; Fermentation. (322 aa)    
Predicted Functional Partners:
PAE2333
Medium-chain acyl-CoA ligase; Fatty acid and phospholipid metabolism; Degradation.
  
 
 0.823
dtdA
Conserved hypothetical protein; D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
       0.763
leuC
3-isopropylmalate dehydratase large subunit (leuC); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
   
 
 0.596
PAE2335
Possible succinyl-diaminopimelate desuccinylase; Amino acid biosynthesis; Aspartate family.
     
 0.572
PAE2330
Sugar transporter, conjectural; Transport and binding proteins; Carbohydrates, organic alcohols, and acids.
     
 0.437
PAE2480
Aldehyde dehydrogenase; Unclassified.
  
 
 0.431
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
 
 0.425
PAE2687
Alcohol dehydrogenase (Zinc); Energy metabolism; Fermentation.
 
  
0.425
pgk
Phosphoglycerate kinase; Energy metabolism; Glycolysis/gluconeogenesis; Belongs to the phosphoglycerate kinase family.
  
 
 0.424
PAE2328
Conserved hypothetical protein.
       0.414
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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