Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE2336Conserved hypothetical protein. (274 aa)    
Predicted Functional Partners:
PAE0270
Transport and binding proteins; Unknown substrate.
 
  
 0.708
thiI
Thiamine biosynthesis protein (thiI), probable; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
     
 0.699
PAE0316
ABC-2 type transport system, membrane protein; Transport and binding proteins; Unknown substrate.
  
  
 0.663
PAE3065
ABC-2 type transport system, membrane protein; Transport and binding proteins; Unknown substrate.
  
  
 0.663
guaA
GMP synthetase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
  
  
 0.595
PAE2337
Hypothetical protein.
       0.585
PAE2338
Ubiquinone/menaquinone biosynthesis methyltransferase (ubiE), conjectural; Biosynthesis of cofactors, prosthetic groups, and carriers; Menaquinone and ubiquinone.
       0.585
PAE1379
long-chain-fatty-acid--CoA ligase; Fatty acid and phospholipid metabolism; Degradation.
   
 
 0.582
PAE2333
Medium-chain acyl-CoA ligase; Fatty acid and phospholipid metabolism; Degradation.
   
 
 0.582
PAE2466
long-chain-fatty-acid--CoA ligase; Fatty acid and phospholipid metabolism; Degradation.
   
 
 0.582
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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