STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. (309 aa)    
Predicted Functional Partners:
PAE1689
Citrate synthase; Energy metabolism; TCA cycle.
  
 0.988
PAE3584
Citrate synthase part 1, authentic frameshift; Energy metabolism; TCA cycle.
  
 0.988
PAE3585
Citrate synthase part 2, authentic frameshift; Energy metabolism; TCA cycle.
  
 0.988
PAE1651
Isocitrate dehydrogenase; Energy metabolism; TCA cycle.
  
 
 0.987
PAE2743
Fumarate hydratase class II; Energy metabolism; TCA cycle.
  
 0.987
PAE2131
Fumarate hydratase class I beta subunit; Energy metabolism; TCA cycle.
  
 
 0.985
PAE2132
Fumarate hydratase class I alpha subunit; Energy metabolism; TCA cycle.
  
 
 0.985
PAE1287
Malate synthase (glcB); Central intermediary metabolism; Other.
   
 0.954
PAE1688
Malate oxidoreductase (mae); Energy metabolism; Other.
  
 0.946
PAE2251
Aspartate aminotransferase (aspC), conjectural; Amino acid biosynthesis; Aspartate family.
  
 0.940
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.