Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE2371NADH oxidase (nox); Cellular processes; Toxin production and resistance. (448 aa)    
Predicted Functional Partners:
PAE2420
Cystathionine gamma-synthase; Amino acid biosynthesis; Aspartate family.
  
 
 0.916
PAE1331
Conserved iron-sulfur protein; Unclassified.
  
 
 0.910
PAE2618
Flavoprotein reductase, conjectural; Energy metabolism; Electron transport.
    
  0.903
PAE2834
Conserved hypothetical protein.
    
  0.903
PAE2614
Nitrate reductase gamma subunit (narI); Energy metabolism; Electron transport.
    
  0.901
PAE2730
Selenium binding protein, probable; Transport and binding proteins; Other.
     
  0.900
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily.
  
 
 0.688
PAE2366
Glutaredoxin-like protein; Purines, pyrimidines, nucleosides, and nucleotides; 2'-Deoxyribonucleotide metabolism.
   
 
 0.642
PAE3381
Beta-lactamase-like protein; Cellular processes; Toxin production and resistance.
 
 
 0.611
PAE2365
Nucleoside-triphosphatase (NTPase); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
 
    0.572
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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