Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PAE2374Hypothetical protein. (40 aa)    
Predicted Functional Partners:
PAE2085
Peroxiredoxin, probable; Cellular processes; Toxin production and resistance.
  
 0.932
PAE2623
Mercuric reductase; Cellular processes; Toxin production and resistance; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
  
 0.885
PAE2649
Pyruvate dehydrogenase E3 (dihydrolipoamide dehydrogenase); Energy metabolism; Glycolysis/gluconeogenesis.
  
 0.885
PAE1725
Thioredoxin reductase (trxB); Purines, pyrimidines, nucleosides, and nucleotides; 2'-Deoxyribonucleotide metabolism.
  
 
 0.845
PAE2744
Thioredoxin reductase (trxB); Purines, pyrimidines, nucleosides, and nucleotides; 2'-Deoxyribonucleotide metabolism.
  
 
 0.845
PAE3155
Ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
   
 0.809
ndk
Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).
  
 0.797
PAE0696
AAA family ATPase, possible cell division control protein cdc48; Cellular processes; Cell division.
  
 0.781
PAE3171
AAA family ATPase, possible cell division control protein cdc48; Cellular processes; Cell division.
  
 0.781
PAE1861
Hypothetical protein with 4 ankyrin repeats; Unclassified.
  
 0.777
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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