Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE2420Cystathionine gamma-synthase; Amino acid biosynthesis; Aspartate family. (383 aa)    
Predicted Functional Partners:
PAE3655
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Amino acid biosynthesis; Aspartate family.
 
 
 0.978
PAE1051
Cysteine synthase; Amino acid biosynthesis; Serine family.
 
 
 0.969
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 
 0.953
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 0.948
PAE2868
Homoserine dehydrogenase; Amino acid biosynthesis; Aspartate family.
 
 
 0.946
ilvE
Branched-chain amino acid aminotransferase (ilvE); Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.942
PAE2618
Flavoprotein reductase, conjectural; Energy metabolism; Electron transport.
  
 
 0.919
PAE2371
NADH oxidase (nox); Cellular processes; Toxin production and resistance.
  
 
 0.916
PAE2834
Conserved hypothetical protein.
  
 
 0.916
PAE2571
Sulfite reductase beta subunit; Central intermediary metabolism; Sulfur metabolism.
   
 
  0.905
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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