Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tdkThymidine kinase; Purines, pyrimidines, nucleosides, and nucleotides; Nucleotide and nucleoside interconversions. (185 aa)    
Predicted Functional Partners:
tmk
Thymidylate kinase (tmk); Purines, pyrimidines, nucleosides, and nucleotides; Nucleotide and nucleoside interconversions.
  
 
 0.947
PAE0794
Cytidine deaminase; Purines, pyrimidines, nucleosides, and nucleotides; Pyrimidine ribonucleotide biosynthesis.
    
 0.940
thyX
Conserved hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
 0.926
PAE3111
Uridine phosphorylase; Purines, pyrimidines, nucleosides, and nucleotides; Salvage of nucleosides and nucleotides.
    
 0.916
surE1
surE stationary-phase survival protein homolog; Nucleotidase that shows the greatest phosphatase activity on purine (deoxy)nucleoside 5'-monophosphates, particularly the substrates 5'-GMP, 5'-AMP and 2'-deoxy-5'-AMP; Belongs to the SurE nucleotidase family.
  
  
  0.912
surE2
surE stationary-phase survival protein homolog; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
  0.900
PAE2452
paREP13; Hypothetical; Conserved within genome.
       0.773
PAE2454
Conserved hypothetical protein.
       0.739
PAE2455
Protein synthesis; Ribosomal proteins: synthesis and modification.
       0.737
pyrG
CTP synthase (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
  
  
 0.688
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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