Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE2458Tryptophan synthase alpha subunit; Amino acid biosynthesis; Aromatic amino acid family. (233 aa)    
Predicted Functional Partners:
trpC
Indole-3-glycerol-phosphate synthase; Amino acid biosynthesis; Aromatic amino acid family; Belongs to the TrpC family.
 
 
 0.998
trpB
Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
   
 0.997
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
  
 0.996
PAE2459
Anthranilate synthase component II; Amino acid biosynthesis; Aromatic amino acid family.
 
  
 0.995
PAE0257
Tryptophan synthase beta subunit (trpB), authentic frameshift; Amino acid biosynthesis; Aromatic amino acid family.
   
 0.982
PAE2460
Anthranilate synthase component I; Amino acid biosynthesis; Aromatic amino acid family.
 
  
 0.979
trpF
Phosphoribosyl anthranilate isomerase; Amino acid biosynthesis; Aromatic amino acid family; Belongs to the TrpF family.
 
  
 0.979
PAE2316
Threonine dehydratase (ilvA); Amino acid biosynthesis; Pyruvate family.
  
 
 0.936
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.932
PAE2017
Phosphoserine phosphatase (serB); Amino acid biosynthesis; Serine family.
    
 0.915
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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