Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-expression
Experiments
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[Homology]
Score
PAE2469Conserved hypothetical protein. (131 aa)    
Predicted Functional Partners:
PAE2467
Fatty acid co-A racemase, conjectural; Fatty acid and phospholipid metabolism; Degradation.
     
 0.800
PAE2464
ABC transporter ATP-binding component; Transport and binding proteins; Amino acids, peptides and amines.
  
  
 0.753
PAE2466
long-chain-fatty-acid--CoA ligase; Fatty acid and phospholipid metabolism; Degradation.
 
  
 0.717
thiI
Thiamine biosynthesis protein (thiI), probable; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
       0.651
PAE2471
acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.
  
  
 0.564
PAE1650
enoyl-CoA hydratase, probable; Fatty acid and phospholipid metabolism; Degradation.
  
  
 0.512
PAE2479
enoyl-CoA hydratase; Fatty acid and phospholipid metabolism; Degradation.
  
  
 0.512
PAE2138
Conserved hypothetical protein.
  
     0.501
PAE2472
Conserved protein associated with acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.
       0.492
queC
Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
 
 
 
 0.481
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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