PAE2568 protein (Pyrobaculum aerophilum) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

PAE2568

Conserved hypothetical protein. (116 aa)

Predicted Functional Partners:

PAE2566

0.611

thiI

0.539

PAE2712

0.443

PAE0681

0.428

PAE2839

0.425

PAE3574

0.425

Your Current Organism:

Pyrobaculum aerophilum

NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PAE0681	PAE2568	PAE0681	PAE2568	Conserved hypothetical protein; Belongs to the UPF0179 family.	Conserved hypothetical protein.	0.428
PAE0681	PAE3574	PAE0681	PAE3574	Conserved hypothetical protein; Belongs to the UPF0179 family.	Conserved hypothetical protein.	0.436
PAE2566	PAE2568	PAE2566	PAE2568	Siroheme-sulfite reductase gamma subunit homolog; Central intermediary metabolism; Sulfur metabolism.	Conserved hypothetical protein.	0.611
PAE2566	thiI	PAE2566	PAE3421	Siroheme-sulfite reductase gamma subunit homolog; Central intermediary metabolism; Sulfur metabolism.	Thiamine biosynthesis protein (thiI), probable; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.	0.666
PAE2568	PAE0681	PAE2568	PAE0681	Conserved hypothetical protein.	Conserved hypothetical protein; Belongs to the UPF0179 family.	0.428
PAE2568	PAE2566	PAE2568	PAE2566	Conserved hypothetical protein.	Siroheme-sulfite reductase gamma subunit homolog; Central intermediary metabolism; Sulfur metabolism.	0.611
PAE2568	PAE2712	PAE2568	PAE2712	Conserved hypothetical protein.	Conserved hypothetical protein.	0.443
PAE2568	PAE2839	PAE2568	PAE2839	Conserved hypothetical protein.	Molybdopterin oxidoreductase, molybdopterin binding subunit part 2, authentic frameshift; Energy metabolism; Electron transport.	0.425
PAE2568	PAE3574	PAE2568	PAE3574	Conserved hypothetical protein.	Conserved hypothetical protein.	0.425
PAE2568	thiI	PAE2568	PAE3421	Conserved hypothetical protein.	Thiamine biosynthesis protein (thiI), probable; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.	0.539
PAE2712	PAE2568	PAE2712	PAE2568	Conserved hypothetical protein.	Conserved hypothetical protein.	0.443
PAE2712	thiI	PAE2712	PAE3421	Conserved hypothetical protein.	Thiamine biosynthesis protein (thiI), probable; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.	0.435
PAE2839	PAE2568	PAE2839	PAE2568	Molybdopterin oxidoreductase, molybdopterin binding subunit part 2, authentic frameshift; Energy metabolism; Electron transport.	Conserved hypothetical protein.	0.425
PAE2839	PAE3574	PAE2839	PAE3574	Molybdopterin oxidoreductase, molybdopterin binding subunit part 2, authentic frameshift; Energy metabolism; Electron transport.	Conserved hypothetical protein.	0.452
PAE3574	PAE0681	PAE3574	PAE0681	Conserved hypothetical protein.	Conserved hypothetical protein; Belongs to the UPF0179 family.	0.436
PAE3574	PAE2568	PAE3574	PAE2568	Conserved hypothetical protein.	Conserved hypothetical protein.	0.425
PAE3574	PAE2839	PAE3574	PAE2839	Conserved hypothetical protein.	Molybdopterin oxidoreductase, molybdopterin binding subunit part 2, authentic frameshift; Energy metabolism; Electron transport.	0.452
thiI	PAE2566	PAE3421	PAE2566	Thiamine biosynthesis protein (thiI), probable; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.	Siroheme-sulfite reductase gamma subunit homolog; Central intermediary metabolism; Sulfur metabolism.	0.666
thiI	PAE2568	PAE3421	PAE2568	Thiamine biosynthesis protein (thiI), probable; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.	Conserved hypothetical protein.	0.539
thiI	PAE2712	PAE3421	PAE2712	Thiamine biosynthesis protein (thiI), probable; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.	Conserved hypothetical protein.	0.435