Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
PAE2578Conserved hypothetical protein. (288 aa)    
Predicted Functional Partners:
thiI
Thiamine biosynthesis protein (thiI), probable; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
  
 0.722
PAE2575
Phosphoadenosine phosphosulfate reductase (PAPS reductase); Central intermediary metabolism; Sulfur metabolism.
 
  
 0.711
PAE2577
Ferredoxin-nitrite reductase; Energy metabolism; Electron transport.
     
 0.636
PAE0727
Molybdenum cofactor biosynthesis protein D/E; Biosynthesis of cofactors, prosthetic groups, and carriers; Molybdopterin.
       0.602
PAE2582
Thiosulfate sulfurtransferase; Central intermediary metabolism; Sulfur metabolism.
       0.559
PAE2580
Conserved hypothetical protein.
       0.556
PAE2574
Hypothetical protein.
       0.541
PAE2576
Hypothetical protein.
       0.541
PAE0443
Conserved protein; Cell envelope; Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides.
  
     0.528
PAE2795
Serine protease; Protein fate; Degradation of proteins, peptides, and glycopeptides.
 
 
 
 0.520
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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