STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAE2587Cobyrinic acid a,c-diamide synthase (cbiA) part 2, authentic frameshift; Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin. (375 aa)    
Predicted Functional Partners:
PAE0343
Cobalamin biosynthesis putative precorrin-8X methylmutase (precorrin isomerase); Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin.
 
 
 0.992
PAE0370
cob(I)alamin adenosyltransferase; Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin.
 
 
 0.969
cbiT
Cobalamin biosynthesis precorrin-8W decarboxylase (cbiT); Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
  
 0.950
PAE0344
Cobalamin biosynthesis precorrin-3 methylase (cbiF); Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin.
 
  
 0.913
PAE0348
Cobalamin biosynthesis precorrin-3 methylase (cbiF); Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin; Belongs to the precorrin methyltransferase family.
 
  
 0.909
cbiD
Cobalamin biosynthesis protein D (cbiD); Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
 
  
 0.900
PAE0339
Cobalamin biosynthesis protein G (cbiG); Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin.
 
  
 0.899
PAE0381
Cobalamin biosynthesis protein B (cbiB); Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin.
 
  
 0.898
PAE0349
Cobalamin biosynthesis precorrin-3 methylase (cbiF); Biosynthesis of cofactors, prosthetic groups, and carriers; Heme, porphyrin and cobalamin; Belongs to the precorrin methyltransferase family.
 
  
 0.821
PAE0372
Conserved hypothetical protein; Belongs to the UPF0284 family.
  
  
 0.791
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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