STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAE2648Pyruvate dehydrogenase E2 (dihydrolipoamide acetyltransferase); Energy metabolism; Glycolysis/gluconeogenesis. (383 aa)    
Predicted Functional Partners:
PAE2644
Pyruvate dehydrogenase E1 alpha subunit; Energy metabolism; Glycolysis/gluconeogenesis.
 
 0.999
PAE2646
Pyruvate dehydrogenase E1 beta subunit; Energy metabolism; Glycolysis/gluconeogenesis.
 
 0.999
PAE2649
Pyruvate dehydrogenase E3 (dihydrolipoamide dehydrogenase); Energy metabolism; Glycolysis/gluconeogenesis.
 0.999
sucC
succinyl-CoA synthetase beta subunit (sucC); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.997
sucD
succinyl-CoA synthetase alpha subunit (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 0.993
PAE2623
Mercuric reductase; Cellular processes; Toxin production and resistance; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
 0.993
PAE1689
Citrate synthase; Energy metabolism; TCA cycle.
  
 0.982
PAE3584
Citrate synthase part 1, authentic frameshift; Energy metabolism; TCA cycle.
  
 0.982
PAE3585
Citrate synthase part 2, authentic frameshift; Energy metabolism; TCA cycle.
  
 0.982
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).
 
 0.976
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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