Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PAE2660Hypothetical protein. (234 aa)    
Predicted Functional Partners:
PAE2661
Formate dehydrogenase beta subunit; Energy metabolism; Electron transport.
    
 0.983
PAE2662
Formate dehydrogenase alpha subunit; Energy metabolism; Electron transport.
    
 0.967
PAE2659
Formate dehydrogenase protein fdhE; Energy metabolism; Electron transport.
       0.826
PAE1287
Malate synthase (glcB); Central intermediary metabolism; Other.
     
  0.800
PAE1688
Malate oxidoreductase (mae); Energy metabolism; Other.
     
  0.800
PAE2131
Fumarate hydratase class I beta subunit; Energy metabolism; TCA cycle.
     
  0.800
PAE2132
Fumarate hydratase class I alpha subunit; Energy metabolism; TCA cycle.
     
  0.800
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily.
     
  0.800
PAE2743
Fumarate hydratase class II; Energy metabolism; TCA cycle.
     
  0.800
ppcA
Conserved hypothetical protein; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family.
     
  0.800
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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