Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE2690Iron-sulfur protein, putative; Energy metabolism; Electron transport. (154 aa)    
Predicted Functional Partners:
PAE0716
Succinate dehydrogenase flavoprotein subunit (sdhA); Energy metabolism; TCA cycle.
 
 0.991
PAE0718
Succinate dehydrogenase cytochrome b subunit (sdhC); Energy metabolism; TCA cycle.
  
 0.984
PAE0719
Succinate dehydrogenase subunit D (sdhD); Energy metabolism; TCA cycle.
  
 
 0.956
PAE1349
Rieske iron sulfur protein (parR); Energy metabolism; Electron transport.
  
 
 0.950
PAE2563
Adenylylsulfate reductase alpha subunit part 1, authentic frameshift; Central intermediary metabolism; Sulfur metabolism.
  
 0.949
PAE2564
Adenylylsulfate reductase alpha subunit part 2, authentic frameshift; Central intermediary metabolism; Sulfur metabolism.
  
 0.949
PAE1580
NADH-ubiquinone oxidoreductase subunit; Energy metabolism; Electron transport.
  
 
 0.946
sucD
succinyl-CoA synthetase alpha subunit (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.892
PAE0368
Protease; Protein fate; Degradation of proteins, peptides, and glycopeptides.
  
 
 0.881
PAE2928
NADH-ubiquinone oxidoreductase subunit; Energy metabolism; Electron transport; Belongs to the complex I 20 kDa subunit family.
  
 
 0.876
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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