Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
PAE26934-hydroxyphenylacetate-3-hydroxylase, conjectural; Central intermediary metabolism; Other. (500 aa)    
Predicted Functional Partners:
PAE1383
3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase; Fatty acid and phospholipid metabolism; Degradation.
 
  
 0.934
PAE2474
Acetyl-coenzyme A synthetase; Fatty acid and phospholipid metabolism; Degradation.
    
 0.903
PAE2691
Conserved protein with 2 CBS domains; Unclassified.
       0.799
PAE2480
Aldehyde dehydrogenase; Unclassified.
     
 0.602
PAE2479
enoyl-CoA hydratase; Fatty acid and phospholipid metabolism; Degradation.
 
   
 0.424
PAE2695
Hypothetical; Conserved within genome.
       0.411
PAE1295
Conserved hypothetical protein.
  
  
 0.403
PAE2058
Conserved hypothetical protein.
  
  
 0.403
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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