Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE2744Thioredoxin reductase (trxB); Purines, pyrimidines, nucleosides, and nucleotides; 2'-Deoxyribonucleotide metabolism. (329 aa)    
Predicted Functional Partners:
PAE1725
Thioredoxin reductase (trxB); Purines, pyrimidines, nucleosides, and nucleotides; 2'-Deoxyribonucleotide metabolism.
  
  
 
0.908
PAE2085
Peroxiredoxin, probable; Cellular processes; Toxin production and resistance.
  
 
 0.862
PAE2374
Hypothetical protein.
  
 
 0.845
PAE2366
Glutaredoxin-like protein; Purines, pyrimidines, nucleosides, and nucleotides; 2'-Deoxyribonucleotide metabolism.
 
 
 0.783
thiI
Thiamine biosynthesis protein (thiI), probable; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
  
 0.744
guaA
GMP synthetase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
 
    0.715
PAE1056
thiF/moeB/hesA family protein; Unclassified.
  
    0.675
PAE0727
Molybdenum cofactor biosynthesis protein D/E; Biosynthesis of cofactors, prosthetic groups, and carriers; Molybdopterin.
  
  
 0.625
cysS
cysteinyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation.
 
  
 0.542
PAE2480
Aldehyde dehydrogenase; Unclassified.
  
  
 0.534
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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