Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE2795Serine protease; Protein fate; Degradation of proteins, peptides, and glycopeptides. (315 aa)    
Predicted Functional Partners:
PAE2024
Conserved hypothetical protein.
  
 0.892
PAE1861
Hypothetical protein with 4 ankyrin repeats; Unclassified.
 
 0.886
PAE1650
enoyl-CoA hydratase, probable; Fatty acid and phospholipid metabolism; Degradation.
   
 0.841
PAE2479
enoyl-CoA hydratase; Fatty acid and phospholipid metabolism; Degradation.
   
 0.841
rps9
Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the universal ribosomal protein uS9 family.
   
 
 0.784
rps13
Ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family.
   
   0.764
rpl11
Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family.
   
   0.754
rps5
Ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy.
  
 
 0.745
rpl14
Ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.
  
 
 0.745
rpl13
Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
  
   0.743
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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