Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PAE2806Conserved hypothetical protein. (205 aa)    
Predicted Functional Partners:
PAE2808
Conserved hypothetical protein; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
       0.792
rps5
Ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy.
    
 0.762
PAE2928
NADH-ubiquinone oxidoreductase subunit; Energy metabolism; Electron transport; Belongs to the complex I 20 kDa subunit family.
    
 0.728
flpA
Fibrillarin-like pre-rRNA processing protein (flpA); Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.
  
 0.664
rps9
Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the universal ribosomal protein uS9 family.
   
  0.659
PAE2926
NADH-ubiquinone oxidoreductase subunit; Energy metabolism; Electron transport.
   
 0.651
rps19e
Ribosomal protein S19; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family.
   
 0.610
rps3ae
Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eS1 family.
   
  0.607
PAE0617
Oxidoreductase, truncation; Unclassified.
    
 0.605
PAE1582
NADH-ubiquinone oxidoreductase subunit; Energy metabolism; Electron transport.
    
 0.605
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.