Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE2865Acetyl-coenzyme A synthetase; Fatty acid and phospholipid metabolism; Degradation. (651 aa)    
Predicted Functional Partners:
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
 
 
0.969
PAE1287
Malate synthase (glcB); Central intermediary metabolism; Other.
  
 0.945
PAE3584
Citrate synthase part 1, authentic frameshift; Energy metabolism; TCA cycle.
  
 0.945
PAE3585
Citrate synthase part 2, authentic frameshift; Energy metabolism; TCA cycle.
  
 0.945
PAE1689
Citrate synthase; Energy metabolism; TCA cycle.
  
 0.944
PAE2480
Aldehyde dehydrogenase; Unclassified.
  
 0.937
PAE1377
acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.
  
 
 0.930
PAE2183
acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.
  
 
 0.930
PAE2471
acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.
  
 
 0.930
PAE1220
acetyl-CoA C-acetyltransferase; Fatty acid and phospholipid metabolism; Degradation.
  
 
 0.929
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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