Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PAE2898Conserved protein with 2 CBS domains; Unclassified. (139 aa)    
Predicted Functional Partners:
PAE2899
Conserved hypothetical protein.
       0.736
PAE2901
Conserved hypothetical protein.
       0.736
PAE2895
Conserved hypothetical protein, authentic frameshift.
   
   0.727
PAE2897
Hypothetical; Conserved within genome.
       0.700
guaA
GMP synthetase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
  
 
 0.659
PAE3333
Conserved hypothetical protein.
  
 0.642
rps9
Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the universal ribosomal protein uS9 family.
  
   0.631
rps2
Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the universal ribosomal protein uS2 family.
  
   0.620
rps4
Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
  
 
 0.602
rpl3
Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.
   
 
 0.599
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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