Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE2919pmbA, putative modulator of DNA gyrase; DNA metabolism; DNA replication, recombination, and repair. (427 aa)    
Predicted Functional Partners:
PAE2918
tldD, putative modulator of DNA gyrase; DNA metabolism; DNA replication, recombination, and repair.
 
   
0.948
PAE2916
Hypothetical protein.
       0.697
guaA
GMP synthetase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
       0.660
dapAL
Dihydrodipicolinate synthase; Amino acid biosynthesis; Aspartate family; Belongs to the DapA family.
     
 0.595
PAE3259
Conserved hypothetical protein.
   
    0.564
taw3
Conserved hypothetical protein; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family.
       0.478
PAE2191
Pyruvate formate-lyase activating enzyme homolog; Protein fate; Protein modification and repair.
       0.470
PAE2911
P. aerophilum family 453, possible regulatory protein; Regulatory functions; General.
       0.429
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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